Where does MMP-13 come from?

It was originally cloned from human breast cancer tissue [8]. It is produced and secreted from many cell types as a 60-kDa precursor form (proMMP-13), which can be activated to a 48-kDa form via a 50-kDa intermediate by plasmin, MMP-2, MMP-3 and MMP-14 [9], [10].

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