Is doxycycline safe long term?

The safety of long-term doxycycline use (>3 months) has not been adequately studied. Because lower doses of doxycycline and minocycline (a related tetracycline) are frequently used for extended periods to treat acne, it has been presumed that long-term use of doxycycline at an adult dose of 100 mg/day is safe.

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