How does MMP degrade collagen?

The monoclonal antibody recognizes a 6 amino acid sequence at position 764 in the C-terminus of type 1 collagen (Leeming et al., 2011b). The collagen degradation fragment is generated by MMPs 2, 9 and 13 and is destroyed by cathepsin K, making this a soft tissue specific marker not originating from bone turnover.

Leave a Comment