Physiologically MMP-13 activity is controlled by naturally occurring inhibitors such as α-macroglobulins and tissue inhibitors of metalloproteinases. 20 23 However, these natural inhibitors do not specifically inhibit MMP-13 to the extent that would be necessary for therapeutic intervention.
The main types of enzymes which are responsible for collagen degradation are collagenases, which belong to a group of enzymes called matrix metalloproteinases (MMPs.) Collagenases are released by several cells in the body including macrophages, fibroblasts, neutrophils and tumor cells.Aug 29, 2019
With their ability to cut the triple helical protein chains of collagen, collagenase enzymes work by targeting all forms of mammalian collagen, resulting in cell isolation. More specifically, collagenase enzymes work by degrading the collagen found in the extracellular matrix.Feb 21, 2019
Matrix metalloproteinase-13 (MMP-13), an important member of matrix metalloproteinases (MMPs) family, plays a vital role by degrading type II collagen in articular cartilage and bone in OA. Thus, developing selective MMP-13 inhibitors is a potential strategy for the therapy of OA.
One mechanism to inhibit MMP activity is by dislodging the enzymes from their receptors. Gold salts bind to a heavy metal site distinct form the zinc-containing active center, which inhibits their activity. MMP activity can be decreased by binding to the cleavage site on the substrate e.g. catechin.
Matrix metalloproteinases (MMPs), a group of zinc-dependent endopeptidases involved in the degradation of the extracellular matrix, play an important role in tissue remodeling associated with various physiological processes such as morphogenesis, angiogenesis, and tissue repair, as well as pathological processes Jun 27, 2014
The extracellular matrix (ECM) is an intricate network composed of an array of multidomain macromolecules organized in a cell/tissue-specific manner. Components of the ECM link together to form a structurally stable composite, contributing to the mechanical properties of tissues.
Age-related dermal ECM alterations impair skin dermis structural and mechanical properties and create a tissue microenvironment that promotes age-related skin diseases, such as thinning , increased fragility , impaired vasculature support [13,14], and poor wound healing .