Will Strep Throat Go Away on Its Own? Strep throat typically goes away in three to seven days with or without antibiotic treatment. However, if you don’t take antibiotics, you can remain contagious for two to three weeks and are at a higher risk for complications, such as rheumatic fever.
For those patients with mild sensitivity to amoxicillin, acceptable alternatives include cefdinir (Omnicef), cefpodoxime (Cefzil), or cefuroxime (Ceftin). These agents, along with amoxicillin-clavulanate (Augmentin), are also commonly used as second or third line therapy.